GutLuk: A Powerful Natural AGP Alternative to Boost Poultry Health and Egg Production

Gutluk is a natural animal growth promoter (AGP) alternative that regulates intestinal microbiota through inhibition of bile salt hydrolase (BSH). It is developed by CJ Bio via machine learning technology to screen key ingredients as BSH inhibitors (BSHI).  

It is well known that enteric diseases are mostly caused by overgrowth of intestinal pathogens, leading to increased competition for nutrients and reduced productivity.  AGP has been widely used to control the overgrowth of enteric pathogens and increase productivity. It is noticed that the use of AGP significantly reduced BSH activity that is protecting pathogens from bactericidal activity of bile salt. However, due to development of antibiotics resistance in farm animals, lots of AGP alternatives such as prebiotics, probiotics, organic acids, enzymes and plant extracts have been promoted, but only antibiotics and high dose of ZnO and CuSO₄ have been shown to inhibit BSH.  Compared with other AGP alternatives, Gutluk  showed super bactericidal effect on Enterotoxigenic E.coli (ETEC), C.perfringens, and S. gallinarum (Table 1). In addition, Gutluk showed greater anti-inflammation and anti-oxidative effects than other AGP alternative (Figure 1).

Table 1. Bactericidal effect of Gutluk on strains of ETEC, C.perfringens, and S. gallinarum

Figure 1. Effect of Gutluk on anti-inflammation (IL-8 reduction) and anti-oxidative functions

In Indonesia, one commercial trial with 6000 Hy-line hens was conducted to show that after two weeks of adaption period (without Gutluk addition), adding 300 g Gutluk per MT feed significantly increased egg production (Figure 2), daily egg Mass was increased by 4.4% and feed conversion ratio was improved by 9 points. Thus, Gutluk is a natural product inhibiting BSH activity and effectively replaces AGP targeting to control intestinal pathogens and improve the egg production as well.

A study compiled by our Redox Animal Nutritionists.